Direct effects of phenformin on metabolism/bioenergetics and viability of SH‑SY5Y neuroblastoma cells

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Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells.

Phenformin, a member of the biguanides class of drugs, has been reported to be efficacious in cancer treatment. The focus of the current study was to establish whether there were direct effects of phenformin on the metabolism and bioenergetics of neuroblastoma SH-SY5Y cancer cells. Cell viability was assessed using the alamar blue assay, flow cytometry analysis using propidium iodide and annexi...

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ژورنال

عنوان ژورنال: Oncology Letters

سال: 2017

ISSN: 1792-1074,1792-1082

DOI: 10.3892/ol.2017.6929